HORDB

ID: hor004613
Uniprot ID: Q7ZXZ6
Protein name: Augurin
Gene name: ecrg4
Organism: Xenopus laevis (African clawed frog)
Family: Augurin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: GO:0005576 extracellular region; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0016324 apical plasma membrane

Sequence: QLWDRTRPEVQQWYQQFLYMGFDEAKYEDDMSYWKNQGRGGSEYYGGFHQHHYDEDAAIGPR
Length: 62
Propeptide: MVVLLFLLVILLCPDSTNGNKLRKMLQKREAVEPSKPIVSVKESKANEFLNSLKRPKRQLWDRTRPEVQQWYQQFLYMGFDEAKYEDDMSYWKNQGRGGSEYYGGFHQHHYDEDAAIGPRNPYTYRHGAGVNYDDY
Signal peptide: MVVLLFLLVILLCPDSTNG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: May attenuate cell proliferation and induce senescence in the central nervous system.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004613_AF2.pdb

hor004613_ESM.pdb

Mass:	867139	Formula:	C341H469N93O103S2
Absent amino acids:	C	Common amino acids:	GQYD
pI:	4.66	Basic residues:	9
Polar residues:	18	Hydrophobic residues:	13
Hydrophobicity:	-142.1	Boman Index:	-17546
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	28.39
Instability Index:	5765	Extinction Coefficient cystines:	26930
Absorbance 280nm:	441.48