HORDB

ID: hor004612
Uniprot ID: Q5FVX5
Protein name: Augurin
Gene name: ecrg4
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Family: Augurin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Silurana (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: GO:0005576 extracellular region; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0016324 apical plasma membrane

Sequence: QLWDRTRPEVQQWYQQFLYMGFDEQKYEDDLSYWMSQGRGGSEYYGGFHQHHYDEDAPIGPR
Length: 62(58-119)
Propeptide: MVLLFLLVIFLCPGSTNGNKLRLMLQKREAGEPSKTIVSVKENKANEFLNSLKRPKRQLWDRTRPEVQQWYQQFLYMGFDEQKYEDDLSYWMSQGRGGSEYYGGFHQHHYDEDAPIGPRNPYTFRHGAGVNYDDY
Signal peptide: MVLLFLLVIFLCPGSTNG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: May attenuate cell proliferation and induce senescence in the central nervous system.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004612_AF2.pdb

hor004612_ESM.pdb

Mass:	871243	Formula:	C344H472N92O104S2
Absent amino acids:	CN	Common amino acids:	QGY
pI:	4.44	Basic residues:	8
Polar residues:	18	Hydrophobic residues:	12
Hydrophobicity:	-139.35	Boman Index:	-17091
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	31.45
Instability Index:	7200.48	Extinction Coefficient cystines:	26930
Absorbance 280nm:	441.48