HORDB

ID: hor004611
Uniprot ID: Q32KM8
Protein name: Augurin
Gene name: ECRG4
Organism: Bos taurus (Bovine)
Family: Augurin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007417 central nervous system development; GO:0008285 negative regulation of cell population proliferation; GO:0009611 response to wounding; GO:0031145 anaphase-promoting complex-dependent catabolic process; GO:0042127 regulation of cell population proliferation; GO:0070314 G1 to G0 transition; GO:0090398 cellular senescence
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0016324 apical plasma membrane

Sequence: MANSSARPAFLVMTALALLLLLCVGPGGISG
Length: 31
Propeptide: MANSSARPAFLVMTALALLLLLCVGPGGISGNKLKLLLRKREAPAPTMTPVAVQESRAKEFLSSLRRPKRQLWDRSRPEVQQWYQHFLYLGFDEAKFEDDISYWLNRNRNGHDYYDYYQRHYDEDSAIGPRSAHSFRHGASVNYDDY
Signal peptide: MANSSARPAFLVMTALALLLLLCVGPGGISG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: May attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system. ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004611_AF2.pdb

hor004611_ESM.pdb

Mass:	358004	Formula:	C136H231N35O37S3
Absent amino acids:	DEHKQWY	Common amino acids:	L
pI:	8.55	Basic residues:	1
Polar residues:	10	Hydrophobic residues:	16
Hydrophobicity:	134.52	Boman Index:	3488
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	135.48
Instability Index:	2714.84	Extinction Coefficient cystines:	0
Absorbance 280nm:	0