HORDB

ID: hor004610
Uniprot ID: P0CAX4
Protein name: Augurin-B
Gene name: ecrg4b
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Family: Augurin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Danio (genus), Danioninae (subfamily), Danionidae (family), Cyprinoidei (suborder), Cypriniformes (order), Cypriniphysae (superorder), Otophysi, Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007417 central nervous system development; GO:0008285 negative regulation of cell population proliferation; GO:0009611 response to wounding; GO:0031145 anaphase-promoting complex-dependent catabolic process; GO:0042127 regulation of cell population proliferation; GO:0070314 G1 to G0 transition; GO:0090398 cellular senescence
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0016324 apical plasma membrane

Sequence: NVWDRSRPDVQQWIQQFMYMGYDEARLETDLSYWMDQARSNDQGRQHHHDENAPMSQQDPRYNRHGANVNYDYY
Length: 74
Propeptide: MSLHSLCVPTILLISVLSICLSSGGSSDSKLHRILIKRDAKEIESRPKAYISVQQSKAKEFLSGLHRTKRNVWDRSRPDVQQWIQQFMYMGYDEARLETDLSYWMDQARSNDQGRQHHHDENAPMSQQDPRYNRHGANVNYDYY
Signal peptide: MSLHSLCVPTILLISVLS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Required for the proper formation of the central nervous system by attenuating cell proliferation during development
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004610_AF2.pdb

hor004610_ESM.pdb

Mass:	1042905	Formula:	C393H563N121O126S4
Absent amino acids:	CK	Common amino acids:	DQ
pI:	4.97	Basic residues:	11
Polar residues:	21	Hydrophobic residues:	14
Hydrophobicity:	-159.73	Boman Index:	-27253
Half-Life:	1.4 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	32.97
Instability Index:	6290	Extinction Coefficient cystines:	26930
Absorbance 280nm:	368.9