HORDB

ID: hor004604
Uniprot ID: Q9I954
Protein name: Thymosin beta-b
Gene name: NA
Organism: Cyprinus carpio (Common carp)
Family: Thymosin beta family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Cyprinus (genus), Cyprininae (subfamily), Cyprinidae (family), Cyprinoidei (suborder), Cypriniformes (order), Cypriniphysae (superorder), Otophysi, Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0003779 actin binding; GO:0003785 actin monomer binding
GO BP: GO:0007015 actin filament organization
GO CC: GO:0005737 cytoplasm; GO:0005856 cytoskeleton

Function: Plays an important role in the organization of the cytoskeleton.
Mechanism: Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004604_AF2.pdb

hor004604_ESM.pdb

Mass:	556986	Formula:	C206H343N55O76S
Absent amino acids:	GHMRWY	Common amino acids:	K
pI:	4.67	Basic residues:	8
Polar residues:	10	Hydrophobic residues:	8
Hydrophobicity:	-150	Boman Index:	-13765
Half-Life / Aliphatic Index:	4.4 hour	Aliphatic Index:	48.81
Instability Index:	3979.52	Extinction Coefficient cystines:	0
Absorbance 280nm:	0