HORDB

ID: hor004601
Uniprot ID: Q9DET5
Protein name: Thymosin beta-15A homolog
Gene name: NA
Organism: Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
Family: Thymosin beta family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Coturnix (genus), Perdicinae (subfamily), Phasianidae (family), Galliformes (order), Galloanserae (superorder), Neognathae (infraclass), Aves (class), Coelurosauria, Theropoda, Saurischia, Dinosauria, Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0003779 actin binding; GO:0003785 actin monomer binding
GO BP: GO:0007015 actin filament organization
GO CC: GO:0005737 cytoplasm; GO:0005856 cytoskeleton

Function: Plays an important role in the organization of the cytoskeleton.
Mechanism: Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004601_AF2.pdb

hor004601_ESM.pdb

Mass:	588092	Formula:	C218H368N58O78S2
Absent amino acids:	AGHMRWY	Common amino acids:	K
pI:	6.58	Basic residues:	11
Polar residues:	12	Hydrophobic residues:	7
Hydrophobicity:	-156.82	Boman Index:	-15109
Half-Life:	1.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	48.64
Instability Index:	5418.86	Extinction Coefficient cystines:	125
Absorbance 280nm:	2.91