HORDB

ID: hor004593
Uniprot ID: O14604
Protein name: Thymosin beta-4
Gene name: TMSB4Y
Organism: Homo sapiens (Human)
Family: Thymosin beta family
Source: Human
Expression: Ubiquitous.
Disease: NA
Comments: NA
Taxonomy: Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0003779 actin binding; GO:0003785 actin monomer binding; GO:0005515 protein binding
GO BP: GO:0007015 actin filament organization; GO:0008064 regulation of actin polymerization or depolymerization; GO:0030334 regulation of cell migration; GO:0042989 sequestering of actin monomers
GO CC: GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton

Function: Plays an important role in the organization of the cytoskeleton.
Mechanism: Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-O14604-F1.pdb

hor004593_AF2.pdb

hor004593_ESM.pdb

Mass:	577973	Formula:	C211H353N59O77S2
Absent amino acids:	CHVWY	Common amino acids:	EK
pI:	5.04	Basic residues:	9
Polar residues:	11	Hydrophobic residues:	7
Hydrophobicity:	-154.55	Boman Index:	-14635
Half-Life / Aliphatic Index:	30 hour	Aliphatic Index:	40
Instability Index:	6684.55	Extinction Coefficient cystines:	0
Absorbance 280nm:	0