HORDB

ID: hor004485
Uniprot ID: P08609
Protein name: Scyliorhinin-2
Gene name: NA
Organism: Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Family: Tachykinin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Scyliorhinus (genus), Scyliorhinidae (family), Carcharhiniformes (order), Galeoidea (superorder), Galeomorphii, Selachii (infraclass), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Function: Excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P08609-F1.pdb

hor004485_AF2.pdb

hor004485_ESM.pdb

Mass:	215750	Formula:	C77H120N20O27S3
Absent amino acids:	AEHIQRTWY	Common amino acids:	PS
pI:	4.11	Basic residues:	1
Polar residues:	8	Hydrophobic residues:	3
Hydrophobicity:	-26.11	Boman Index:	-2110
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	37.78
Instability Index:	4166.11	Extinction Coefficient cystines:	125
Absorbance 280nm:	7.35

PubMed ID: 2422058
Title: Scyliorhinin I and II: two novel tachykinins from dogfish gut.
PubMed ID: 7685693
Title: Characterization of the endogenous intestinal peptide that stimulates the rectal gland of Scyliorhinus canicula.