General Information

  • ID:  hor004483
  • Uniprot ID:  P82470
  • Protein name:  Tachykinin-1
  • Gene name:  NA
  • Organism:  Schistocerca gregaria (Desert locust) (Gryllus gregarius)
  • Family:  Tachykinin family
  • Source:  Animal
  • Expression:  Midgut.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Schistocerca (genus), Cyrtacanthacridinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GNTKKAVPGFYGTR
  • Length:  14(1-14)
  • Propeptide:  GNTKKAVPGFYGTR
  • Signal peptide:  NA
  • Modification:  T14 Arginine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive peptide. Increases the amplitude and frequency of spontaneous contractions and tonus of hindgut muscle.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004483_AF2.pdbhor004483_ESM.pdb

Physical Information

Mass: 172775 Formula: C67H106N20O19
Absent amino acids: CDEHILMQSW Common amino acids: G
pI: 10.9 Basic residues: 3
Polar residues: 7 Hydrophobic residues: 3
Hydrophobicity: -89.29 Boman Index: -2629
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 27.86
Instability Index: 2207.14 Extinction Coefficient cystines: 1490
Absorbance 280nm: 114.62

Literature

  • PubMed ID:  10581195
  • Title:  Identification of a New Tachykinin From the Midgut of the Desert Locust, Schistocerca Gregaria, by ESI-Qq-oa-TOF Mass Spectrometry