General Information

  • ID:  hor004477
  • Uniprot ID:  P81737
  • Protein name:  Tachykinin-related peptide 5
  • Gene name:  NA
  • Organism:  Rhyparobia maderae (Madeira cockroach) (Leucophaea maderae)
  • Family:  Tachykinin family
  • Source:  Animal
  • Expression:  Midgut and brain.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rhyparobia (genus), Oxyhaloinae (subfamily), Blaberidae (family), Blaberoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  APAMGFQGVR
  • Length:  10(1-10)
  • Propeptide:  APAMGFQGVR
  • Signal peptide:  NA
  • Modification:  T10 Arginine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive peptide. Increases the amplitude and frequency of spontaneous contractions and tonus of hindgut muscle.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  10(-9)M
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004477_AF2.pdbhor004477_ESM.pdb

Physical Information

Mass: 119393 Formula: C45H72N14O12S
Absent amino acids: CDEHIKLNSTWY Common amino acids: AG
pI: 10.55 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: 21 Boman Index: -559
Half-Life / Aliphatic Index: 4.4 hour Aliphatic Index: 49
Instability Index: 4752 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  8897641
  • Title:  Isolation of Five Tachykinin-Related Peptides From the Midgut of the Cockroach Leucophaea Maderae: Existence of N-terminally Extended Isoforms.
  • PubMed ID:  9114447
  • Title:  Seven Tachykinin-Related Peptides Isolated From the Brain of the Madeira Cockroach: Evidence for Tissue-Specif