General Information

  • ID:  hor004447
  • Uniprot ID:  P42987
  • Protein name:  Kassinin-like peptide K-II
  • Gene name:  NA
  • Organism:  Pseudophryne guentheri (Guenther's toadlet)
  • Family:  Tachykinin family
  • Source:  animal
  • Expression:  Expressed by the skin glands.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Pseudophryne (genus), Myobatrachinae (subfamily), Myobatrachidae (family), Myobatrachoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0006952 defense response; GO:0007217 tachykinin receptor signaling pathway; GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QPNPDEFVGLM
  • Length:  11(1-11)
  • Propeptide:  QPNPDEFVGLM
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T11 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004447_AF2.pdbhor004447_ESM.pdb

Physical Information

Mass: 142495 Formula: C55H83N13O18S
Absent amino acids: ACHIKRSTWY Common amino acids: P
pI: 3.55 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: -44.55 Boman Index: -1248
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 61.82
Instability Index: 940.91 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  2356157
  • Title:  Six Novel Tachykinin- And Bombesin-Related Peptides From the Skin of the Australian Frog Pseudophryne G篓鹿nther