General Information

  • ID:  hor004445
  • Uniprot ID:  P08615
  • Protein name:  Physalaemin
  • Gene name:  NA
  • Organism:  Physalaemus fuscomaculatus (Neotropical frog) (Physalaemus marmoratus)
  • Family:  Tachykinin family
  • Source:  animal
  • Expression:  Expressed by the skin glands.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Physalaemus (genus), Leiuperinae (subfamily), Leptodactylidae (family), Hyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0006952 defense response; GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QADPNKFYGLM
  • Length:  11(1-11)
  • Propeptide:  QADPNKFYGLM
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T11 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004445_AF2.pdbhor004445_ESM.pdb

Physical Information

Mass: 146202 Formula: C58H86N14O17S
Absent amino acids: CEHIRSTVW Common amino acids: ADFGKLMNPQY
pI: 6.34 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -67.27 Boman Index: -1359
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 44.55
Instability Index: 4481.82 Extinction Coefficient cystines: 1490
Absorbance 280nm: 149

Literature

  • PubMed ID:  5857249
  • Title:  Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus.