HORDB

ID: hor004431
Uniprot ID: P41540
Protein name: C-terminal-flanking peptide
Gene name: Tac1
Organism: Oryctolagus cuniculus (Rabbit)
Family: Tachykinin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Oryctolagus (genus), Leporidae (family), Lagomorpha (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007217 tachykinin receptor signaling pathway; GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission
GO CC: GO:0005576 extracellular region; GO:0045202 synapse

Sequence: ALNSVAYERSAMQNYE
Length: 16(96-111)
Propeptide: MKILVALAVLALVSTQLFAEDIRANDDLNYWSDWSDSDQIKEELPEPFEHLLQRIARRPKPQQFFGLMGKRDAGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRRK
Signal peptide: MKILVALAVLALVSTQLFA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004431_AF2.pdb

hor004431_ESM.pdb

Mass:	211373	Formula:	C78H120N22O28S
Absent amino acids:	CDFGHIKPTW	Common amino acids:	A
pI:	4.26	Basic residues:	1
Polar residues:	6	Hydrophobic residues:	5
Hydrophobicity:	-68.13	Boman Index:	-3770
Half-Life / Aliphatic Index:	4.4 hour	Aliphatic Index:	61.25
Instability Index:	2213.75	Extinction Coefficient cystines:	2980
Absorbance 280nm:	198.67