General Information

  • ID:  hor004422
  • Uniprot ID:  P40951
  • Protein name:  Ranamargarin
  • Gene name:  NA
  • Organism:  Odorrana margaretae (Chinese frog) (Rana margaratae)
  • Family:  Tachykinin family
  • Source:  animal
  • Expression:  Expressed by the skin glands.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Odorrana (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0006952 defense response; GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DDASDRAKKFYGLM
  • Length:  14(1-14)
  • Propeptide:  DDASDRAKKFYGLM
  • Signal peptide:  NA
  • Modification:  T14 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004422_AF2.pdbhor004422_ESM.pdb

Physical Information

Mass: 184888 Formula: C70H109N19O23S
Absent amino acids: CEHINPQTVW Common amino acids: D
pI: 6.51 Basic residues: 3
Polar residues: 3 Hydrophobic residues: 4
Hydrophobicity: -94.29 Boman Index: -4091
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 42.14
Instability Index: 2112.14 Extinction Coefficient cystines: 1490
Absorbance 280nm: 114.62

Literature

  • PubMed ID:  2803524
  • Title:  Isolation and Structure of Ranamargarin, a New Tachykinin From the Skin of Chinese Frog Rana Margaratae