HORDB

ID: hor004420
Uniprot ID: Q8I6S3
Protein name: Tachykinin-1
Gene name: NA
Organism: Octopus vulgaris (Common octopus)
Family: Tachykinin family
Source: animal
Expression: Expressed in the posterior salivary gland and more specifically in the mucus-secreting gland cells.
Disease: NA
Comments: NA
Taxonomy: Octopus (genus), Octopodidae (family), Incirrata (suborder), Octopoda (order), Octopodiformes (superorder), Coleoidea (subclass), Cephalopoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: KPPSSSEFIGLM
Length: 12(38-49)
Propeptide: MIRVGLILCCIFIAGVFEASSADDMLTAHNLIKRSEVKPPSSSEFIGLMGRSEELTRRLIQHPGSMSETSKRGPPKKVSRRPYILKK
Signal peptide: MIRVGLILCCIFIAGVFEASSA
Modification: T12 Methionine amide
Glycosylation: NA
Mutagenesis: NA

Function: Excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004420_AF2.pdb

hor004420_ESM.pdb

Mass:	148888	Formula:	C58H93N13O18S
Absent amino acids:	ACDHNQRTVWY	Common amino acids:	S
pI:	6.41	Basic residues:	1
Polar residues:	4	Hydrophobic residues:	3
Hydrophobicity:	-3.33	Boman Index:	-645
Half-Life:	1.3 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	65
Instability Index:	8313.33	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 12576083
Title: Isolation and Characterization of Novel Tachykinins From the Posterior Salivary Gland of the Common Octopus Octopus Vulgaris