HORDB

ID: hor004407
Uniprot ID: Q60541
Protein name: Neurokinin A
Gene name: Tac1
Organism: Mesocricetus auratus (Golden hamster)
Family: Tachykinin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Mesocricetus (genus), Cricetinae (subfamily), Cricetidae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007217 tachykinin receptor signaling pathway; GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission
GO CC: GO:0005576 extracellular region; GO:0045202 synapse

Sequence: HKTDSFVGLM
Length: 10(98-107)
Propeptide: MKILVAVAVFFLVSTQLSAEEIGANDDLNYWSDWSDSDQIKEALPEPFEHILQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAFERSAMQNYERRRK
Signal peptide: MKILVAVAVFFLVSTQLSA
Modification: T10 Methionine amide
Glycosylation: NA
Mutagenesis: NA

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Mechanism: NA
Cross BBB: NA
Target: Tacr1, TACR2
Target Unid: A0A1U7QPR6, P51144
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004407_AF2.pdb

hor004407_ESM.pdb

Mass:	129503	Formula:	C50H79N13O15S
Absent amino acids:	ACEINPQRWY	Common amino acids:	DFGHKLMSTV
pI:	7.55	Basic residues:	2
Polar residues:	3	Hydrophobic residues:	3
Hydrophobicity:	2	Boman Index:	-967
Half-Life / Aliphatic Index:	3.5 hour	Aliphatic Index:	68
Instability Index:	4345	Extinction Coefficient cystines:	0
Absorbance 280nm:	0