General Information

  • ID:  hor004374
  • Uniprot ID:  P25421
  • Protein name:  Substance P
  • Gene name:  NA
  • Organism:  Carassius auratus (Goldfish)
  • Family:  Tachykinin family
  • Source:  animal
  • Expression:  Expression is induced in the hypothalamus and olfactory bulb after feeding. |Expressed in the brain throughout development, with expression first observable in the nascent diencephalon, olfactory bulbs and hypothalamus shortly after fertilization. |Expres
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Carassius (genus), Cyprininae (subfamily), Cyprinidae (family), Cyprinoidei (suborder), Cypriniformes (order), Cypriniphysae (superorder), Otophysi, Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007217 tachykinin receptor signaling pathway; GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission
  • GO CC:  GO:0005576 extracellular region; GO:0045202 synapse

Sequence Information

  • Sequence:  KPRPHQFIGLM
  • Length:  11(57-67)
  • Propeptide:  MKFLLPSIVIFLVLCQVFGEELGPKEDLDYWTGSNQVQDEWLQADPFREIIRRMTRKPRPHQFIGLMGKRSPANAQITRKRHKINSFVGLMGKRSQEEPESYEWGTVQIYDKRR
  • Signal peptide:  MKFLLPSIVIFLVLCQVFG
  • Modification:  T11 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Substance P produces a voltage-dependent inhibition of calcium current in retinal bipolar cells. It can enhance learning and memory, may regulate social approach and feeding behaviors, and can accelerate the functional recovery in postural balance in resp
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P25421-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor004374_AF2.pdbhor004374_ESM.pdb

Physical Information

Mass: 150217 Formula: C61H98N18O13S
Absent amino acids: ACDENSTVWY Common amino acids: P
pI: 11.65 Basic residues: 3
Polar residues: 1 Hydrophobic residues: 3
Hydrophobicity: -51.82 Boman Index: -1456
Half-Life: 1.3 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 70.91
Instability Index: 603.64 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  NA
  • Title:  NA