General Information

  • ID:  hor004364
  • Uniprot ID:  P01289
  • Protein name:  C-terminal-flanking peptide
  • Gene name:  TAC1
  • Organism:  Bos taurus (Bovine)
  • Family:  Tachykinin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0031835 substance P receptor binding
  • GO BP:  GO:0006954 inflammatory response; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007217 tachykinin receptor signaling pathway; GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0019233 sensory perception of pain; GO:0048265 response to pain
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0030424 axon; GO:0043025 neuronal cell body; GO:0045202 synapse

Sequence Information

  • Sequence:  ALNSVAYERSVMQDYE
  • Length:  16(111-126)
  • Propeptide:  MKILVAVAVIFFISTQLSAEEIGANDDFNYWSDWSDSDQIKEEMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQLSHKRHKTDSFVGLMGKRALNSVAYERSVMQDYERRRK
  • Signal peptide:  MKILVAVAVIFFISTQLSA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  TACR1, TACR2
  • Target Unid:  F1MIX5, P05363
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P01289-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004364_AF2.pdbhor004364_ESM.pdb

Physical Information

Mass: 214277 Formula: C80H123N21O29S
Absent amino acids: CFGHIKPTW Common amino acids: AESVY
pI: 3.93 Basic residues: 1
Polar residues: 5 Hydrophobic residues: 5
Hydrophobicity: -53.13 Boman Index: -3755
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 73.13
Instability Index: 3417.5 Extinction Coefficient cystines: 2980
Absorbance 280nm: 198.67

Literature

  • PubMed ID:  2809597
  • Title:  Quantitation and Characterization of Peptides From the C-terminal Flanking Region of Rat and Bovine Preprotachykinins