General Information

  • ID:  hor004272
  • Uniprot ID:  NA
  • Protein name:  Substance P
  • Gene name:  NA
  • Organism:  Rattus norvegicus
  • Family:  Tachykinin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  RPQQFGLM
  • Length:  8
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T8 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  A potential neurotransmitter or modulator and shortened learning and memorizing processes
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004272_AF2.pdbhor004272_ESM.pdb

Physical Information

Mass: 110120 Formula: C43H69N13O11S
Absent amino acids: ACDEHIKNSTVWY Common amino acids: Q
pI: 10.55 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 2
Hydrophobicity: -62.5 Boman Index: -1481
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 48.75
Instability Index: 7155 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  504332
  • Title:  Conditioned-reflex Learning of Normal Juvenile and Adult Rats Exposed to Action of Substance P and of an SP Analogue