General Information

  • ID:  hor004267
  • Uniprot ID:  Q9PRZ3
  • Protein name:  neuropeptide-gamma-related peptide
  • Gene name:  NA
  • Organism:  Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
  • Family:  Tachykinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Oncorhynchus (genus), Salmoninae (subfamily), Salmonidae (family), Salmoniformes (order), Protacanthopterygii, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0002027 regulation of heart rate; GO:0006940 regulation of smooth muscle contraction; GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission
  • GO CC:  GO:0005576 extracellular region; GO:0045202 synapse

Sequence Information

  • Sequence:  SSANPQITRKRHKINSFVGLM
  • Length:  21
  • Propeptide:  SSANPQITRKRHKINSFVGLM
  • Signal peptide:  NA
  • Modification:  T21 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulated the motility of isolated trout intestinal muscle
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: 4.47*10(-8)M
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9PRZ3-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-Q9PRZ3-F1.pdbhor004267_AF2.pdbhor004267_ESM.pdb

Physical Information

Mass: 274169 Formula: C103H174N34O29S
Absent amino acids: CDEWY Common amino acids: S
pI: 12.53 Basic residues: 5
Polar residues: 7 Hydrophobic residues: 6
Hydrophobicity: -57.62 Boman Index: -5031
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 74.29
Instability Index: 5395.24 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  7694488
  • Title:  Primary Structures and Effects on Gastrointestinal Motility of Tachykinins From the Rainbow Trout