General Information

  • ID:  hor004251
  • Uniprot ID:  NA
  • Protein name:  Substance P
  • Gene name:  NA
  • Organism:  Amphiuma tridactylum
  • Family:  Tachykinin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  DNPSVGQFYGLM
  • Length:  12
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T12 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004251_AF2.pdbhor004251_ESM.pdb

Physical Information

Mass: 152386 Formula: C59H86N14O19S
Absent amino acids: ACEHIKRTW Common amino acids: G
pI: 3.75 Basic residues: 0
Polar residues: 5 Hydrophobic residues: 3
Hydrophobicity: -19.17 Boman Index: -827
Half-Life / Aliphatic Index: 1.1 hour Aliphatic Index: 56.67
Instability Index: 2955 Extinction Coefficient cystines: 1490
Absorbance 280nm: 135.45

Literature

  • PubMed ID:  7479293
  • Title:  Tachykinins with unusual structural features from a urodele, the amphiuma, an elasmobranch, the hammerhead shark, and an agnathan, the river lamprey