General Information

  • ID:  hor004184
  • Uniprot ID:  P09037
  • Protein name:  Angiotensin II
  • Gene name:  AGT
  • Organism:  Crinia georgiana (Quacking frog)
  • Family:  Serpin family
  • Source:  animal
  • Expression:  Skin.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Crinia (genus), Myobatrachinae (subfamily), Myobatrachidae (family), Myobatrachoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0042310 vasoconstriction; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  APGDRIYVHPF
  • Length:  11
  • Propeptide:  APGDRIYVHPF
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q80T19-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-Q80T19-F1.pdbhor004184_AF2.pdbhor004184_ESM.pdb

Physical Information

Mass: 144999 Formula: C60H86N16O15
Absent amino acids: CEKLMNQSTW Common amino acids: P
pI: 7.54 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: -25.45 Boman Index: -1375
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 70.91
Instability Index: 3463.64 Extinction Coefficient cystines: 1490
Absorbance 280nm: 149

Literature

  • PubMed ID:  488254
  • Title:  Amino acid composition and sequence of crinia-angiotensin, an angiotensin II-like endecapeptide from the skin of the Australian frog Crinia georgiana.