General Information

  • ID:  hor004183
  • Uniprot ID:  B7X9Y6
  • Protein name:  Angiotensin I
  • Gene name:  agt
  • Organism:  Triakis scyllium (Banded houndshark) (Hemigaleus pingi)
  • Family:  Serpin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Triakis (genus), Triakidae (family), Carcharhiniformes (order), Galeoidea (superorder), Galeomorphii, Selachii (infraclass), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0004867 serine-type endopeptidase inhibitor activity
  • GO BP:  NA
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  NRPYIHPFQL
  • Length:  10
  • Propeptide:  MRWIFSLLWVGALLEWGTTNRPYIHPFQLFTCNRTEFQEEMDRNNSFLPEQSPVNMSEEWWENELWKVSPTKMFTLISLQMSLAKIWFAKLGSLEESGVTLLSPVHLYESLAALSLGAGGATAKSFREHLGLMDYRCVGDRHSWVMRWQGRLLHHDILTRQEGSVSTGAWLIFRKGLQLRRAFSWELRWFYPQVQLRAADCNQPRVAEETINSLVLNATGGRVSNLVTGLSPSTNLVLASYIHFTGKWQSRSQCQGSELQDFFNDGEDKVQVPMMTWCGKLRYYIDPEYTLIKLPMNGTVYMMLVQPVQSNLLQKIESTLDVNDIMLKTGLVRLTLPRFKWDSTYDAKELYRRMKLPDMLGGQANFSRLNNVQELTPDQVKQRVIFEVLEDEEKPTSADVPFSNTTFTTEIRIDKPFFFQVYDKILSQLLFLGRVKKLH
  • Signal peptide:  MRWIFSLLWVGALLEWGTT
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Regulate blood pressure
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-B7X9Y6-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor004183_AF2.pdbhor004183_ESM.pdb

Physical Information

Mass: 144519 Formula: C61H89N17O14
Absent amino acids: ACDEGKMSTVW Common amino acids: P
pI: 9.35 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: -81 Boman Index: -1908
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 78
Instability Index: 5698 Extinction Coefficient cystines: 1490
Absorbance 280nm: 165.56

Literature

  • PubMed ID:  8308464
  • Title:  A Novel Angiotensin I Isolated From an Elasmobranch Fish