General Information

  • ID:  hor004180
  • Uniprot ID:  NA
  • Protein name:  Angiotensin IV
  • Gene name:  NA
  • Organism:  NA
  • Family:  Serpin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  VYIHPF
  • Length:  6
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Regulate blood pressure
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor004180_AF2.pdbhor004180_ESM.pdb

Physical Information

Mass: 86428 Formula: C40H54N8O8
Absent amino acids: ACDEGKLMNQRSTW Common amino acids: FHIPVY
pI: 7.54 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 3
Hydrophobicity: 90 Boman Index: 714
Half-Life: 100 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 113.33
Instability Index: 4363.33 Extinction Coefficient cystines: 1490
Absorbance 280nm: 298

Literature

  • PubMed ID:  21476495
  • Title:  Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis