HORDB

ID: hor004160
Uniprot ID: Q96RP3
Protein name: Urocortin-2
Gene name: UCN2
Organism: Homo sapiens (Human)
Family: Sauvagine/corticotropin-releasing factor/urotensin I family
Source: Human
Expression: human placenta decidua and fetal membranes
Disease: Diseases associated with UCN2 include Anxiety and Body Mass Index Quantitative Trait Locus 11.
Comments: NA
Taxonomy: Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0001664 G protein-coupled receptor binding; GO:0005179 hormone activity; GO:0042562 hormone binding; GO:0051429 corticotropin-releasing hormone receptor binding; GO:0051431 corticotropin-releasing hormone receptor 2 binding
GO BP: GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway; GO:0007586 digestion; GO:0009755 hormone-mediated signaling pathway; GO:0031669 cellular response to nutrient levels
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: IVLSLDVPIGLLQILLEQARARAAREQATTNARILARVGHC
Length: 41
Propeptide: MTRCALLLLMVLMLGRVLVVPVTPIPTFQLRPQNSPQTTPRPAASESPSAAPTWPWAAQSHCSPTRHPGSRIVLSLDVPIGLLQILLEQARARAAREQATTNARILARVGHC
Signal peptide: MTRCALLLLMVLMLGRVLVVPV
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Suppresses food intake, delays gastric emptying and decreases heat-induced edema; might represent an endogenous ligand for maintaining homeostasis after stress;may play a role in the regulation of estradiol production throughout pregnancy thereby contributing to the placental regulation of key reproductive events in pregnancy maintenance and parturition;be proinflammatory
Mechanism: Ucn 2 induced a central CRF(2)-mediated inhibition of gastric emptying involving sympathetic alpha(1)-adrenergic mechanisms
Cross BBB: YES
Target: CRHR2, CRHR1
Target Unid: Q13324, P34998
IC50: NA
EC50: cAMP rCRF-R2-alpha:0.26nmol;cAMP mCRF-R2-beta:0.42nmol
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q03191-F1.pdb

hor004160_AF2.pdb

hor004160_ESM.pdb

Mass:	516497	Formula:	C194H338N62O55S
Absent amino acids:	FKMWY	Common amino acids:	AL
pI:	10.33	Basic residues:	6
Polar residues:	7	Hydrophobic residues:	21
Hydrophobicity:	42.68	Boman Index:	-5133
Half-Life:	20 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	142.93
Instability Index:	3338.78	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 16223946
Title: Urocortin 2 Acts Centrally to Delay Gastric Emptying Through Sympathetic Pathways While CRF and Urocortin 1 Inhibitory Actions Are Vagal Dependent in Rats
PubMed ID: 19417223
Title: Urocortin 2 Stimulates Estradiol Secretion From Cultured Human Placental Cells: An Effect Mediated by the Type 2 Corticotrophin-Releasing Hormone (CRH) Receptor
PubMed ID: 22000474
Title: Effects of Urocortin 2 and Urocortin 3 on IL-10 and TNF-α Expression and Secretion From Human Trophoblast Explants
PubMed ID: 11416224
Title: Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.