General Information

  • ID:  hor004146
  • Uniprot ID:  A0A7M7LKK3
  • Protein name:  Diuretic hormone 44
  • Gene name:  100679179
  • Organism:  Nasonia vitripennis (Parasitic wasp)
  • Family:  Sauvagine/corticotropin-releasing factor/urotensin I family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Nasonia (genus), Pteromalinae (subfamily), Pteromalidae (family), Chalcidoidea (superfamily), Parasitoida (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  IGSLSVVNSVDVLRERVLLELARRKAMENQQQLGENQYVFKSV
  • Length:  43(108-150)
  • Propeptide:  MSLVSLLATTTLITLATSTPMILAEDVAAAGPFGGAGLRAKIPVDHDHFLLIMLLNRRDFGVKSKPPLDETGGEYITSLDSDMSSSGGGGGFDTGGIAVSDLTRGKRIGSLSVVNSVDVLRERVLLELARRKAMENQQQLGENQYVFKSVGKRSGGFSYRDHRIARKKRLQYQLMNRQQQPERLLAQ
  • Signal peptide:  MSLVSLLATTTLITLATSTPMILA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A7M7LKK3-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004146_AF2.pdbhor004146_ESM.pdb

Physical Information

Mass: 566699 Formula: C214H360N64O66S
Absent amino acids: CHPTW Common amino acids: V
pI: 9.25 Basic residues: 6
Polar residues: 10 Hydrophobic residues: 17
Hydrophobicity: -18.84 Boman Index: -8901
Half-Life / Aliphatic Index: 20 hour Aliphatic Index: 115.35
Instability Index: 2231.16 Extinction Coefficient cystines: 1490
Absorbance 280nm: 35.48

Literature

  • PubMed ID:  20695486
  • Title:  Genomics and Peptidomics of Neuropeptides and Protein Hormones Present in the Parasitic Wasp Nasonia Vitripennis