General Information

  • ID:  hor004111
  • Uniprot ID:  P84358
  • Protein name:  Pyrokinin-4
  • Gene name:  NA
  • Organism:  Periplaneta brunnea (Brown cockroach)
  • Family:  Pyrokinin family
  • Source:  Animal
  • Expression:  Expressed in the brain, subesophageal ganglion and in the retrocerebral complex (mainly corpora allata).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Periplaneta (genus), Blattinae (subfamily), Blattidae (family), Blattoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DHLSHDVYSPRL
  • Length:  12(1-12)
  • Propeptide:  DHLSHDVYSPRL
  • Signal peptide:  NA
  • Modification:  T12 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Mediates visceral muscle contractile activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004111_AF2.pdbhor004111_ESM.pdb

Physical Information

Mass: 163495 Formula: C63H95N19O20
Absent amino acids: ACEFGIKMNQTW Common amino acids: DHLS
pI: 6.5 Basic residues: 3
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -88.33 Boman Index: -3474
Half-Life / Aliphatic Index: 1.1 hour Aliphatic Index: 89.17
Instability Index: 3321.67 Extinction Coefficient cystines: 1490
Absorbance 280nm: 135.45

Literature

  • PubMed ID:  15626499
  • Title:  A proteomic approach for studying insect phylogeny: CAPA peptides of ancient insect taxa (Dictyoptera, Blattoptera) as a test case.