General Information

  • ID:  hor004105
  • Uniprot ID:  P82691
  • Protein name:  Pyrokinin-1
  • Gene name:  NA
  • Organism:  Periplaneta americana (American cockroach) (Blatta americana)
  • Family:  Pyrokinin family
  • Source:  Animal
  • Expression:  Corpora cardiaca.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Periplaneta (genus), Blattinae (subfamily), Blattidae (family), Blattoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  HTAGFIPRL
  • Length:  9(1-9)
  • Propeptide:  HTAGFIPRL
  • Signal peptide:  NA
  • Modification:  T9 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Mediates visceral muscle contractile activity
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004105_AF2.pdbhor004105_ESM.pdb

Physical Information

Mass: 115407 Formula: C47H74N14O11
Absent amino acids: CDEKMNQSVWY Common amino acids: AFGHILPRT
pI: 10.55 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: 27.78 Boman Index: -658
Half-Life: 3.5 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 97.78
Instability Index: -1106.67 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  9210163
  • Title:  Isolation and structural elucidation of two pyrokinins from the retrocerebral complex of the American cockroach.