General Information

  • ID:  hor004059
  • Uniprot ID:  P82684
  • Protein name:  Pyrokinin-1
  • Gene name:  NA
  • Organism:  Carausius morosus (Indian stick insect) (Dixippus morosus)
  • Family:  Pyrokinin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Carausius (genus), Lonchodinae (subfamily), Lonchodidae (family), Anareolatae (infraorder), Verophasmatodea (suborder), Phasmatodea (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DEGGTQYTPRL
  • Length:  11(1-11)
  • Propeptide:  DEGGTQYTPRL
  • Signal peptide:  NA
  • Modification:  T11 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Mediates visceral muscle contractile activity
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004059_AF2.pdbhor004059_ESM.pdb

Physical Information

Mass: 141485 Formula: C52H81N15O20
Absent amino acids: ACFHIKMNSVW Common amino acids: GT
pI: 4.18 Basic residues: 1
Polar residues: 5 Hydrophobic residues: 1
Hydrophobicity: -148.18 Boman Index: -3447
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 35.45
Instability Index: -1569.09 Extinction Coefficient cystines: 1490
Absorbance 280nm: 149

Literature

  • PubMed ID:  NA
  • Title:  Myotropic neuropeptides from the retrocerebral complex of the stick insect, Carausius morosus (Phasmatodea: Lonchodidae).