HORDB

ID: hor003927
Uniprot ID: Q9YGK2
Protein name: Beta-endorphin
Gene name: pomc
Organism: Thunnus obesus (Bigeye tuna)
Family: POMC family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Thunnus (genus), Thunnini (tribe), Scombrinae (subfamily), Scombridae (family), Scombriformes (order), Pelagiaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: YGGFMKSWDERSQRPLLTLFKNVINKDGQQQK
Length: 32(191-222)
Propeptide: MCPVWLLVAVVVVGGSRGAVSQCWEHPSCQELNSDSSMMECIQLCHSDLTAEKPVIPGNAHLQPPPLPDPSSSSSFILPSSSSSSSSPQSKRSYSMEHFRWGKPVGRKRRPVKVYTSNGVEEESAEVFPGEMRRRELASELLAAAEEEEEKAQEVMAEEEEEQKQLLQEKKDGSYKMKHFRWSGPPASKRYGGFMKSWDERSQRPLLTLFKNVINKDGQQQK
Signal peptide: MCPVWLLVAVVVVGGSRG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003927_AF2.pdb

hor003927_ESM.pdb

Mass:	436647	Formula:	C170H267N49O49S
Absent amino acids:	ACH	Common amino acids:	KQ
pI:	10.48	Basic residues:	6
Polar residues:	9	Hydrophobic residues:	8
Hydrophobicity:	-111.88	Boman Index:	-8406
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	57.81
Instability Index:	5140	Extinction Coefficient cystines:	6990
Absorbance 280nm:	225.48