General Information

  • ID:  hor003859
  • Uniprot ID:  Q91082
  • Protein name:  Beta-endorphin
  • Gene name:  pomc
  • Organism:  Lepisosteus osseus (Long-nosed gar) (Esox osseus)
  • Family:  POMC family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Lepisosteus (genus), Lepisosteidae (family), Semionotiformes (order), Holostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YGGFMKSWDERSQKPLLTLFKNVIIKDGHQKKGQ
  • Length:  34(226-259)
  • Propeptide:  MLRSVWVYSLGLAVLLQQSGREQCWEHSQCRDLSSEENILECIQACNSDLTAESPIFPGNGHLQPPSEADRNYAKSHFRSTALGRRTNGSVGSSKQAGENAALSILFAALAPPQAEEEMEESESSQQQRREDKRSYSMEHFRWGKPVGRKRRPVKVYPNGVEEESAEAYPTEMRRDLMSDLDYPLLEEVEEELGGENEVLNLQEKKDGSYKMHHFRWSRPPKDKRYGGFMKSWDERSQKPLLTLFKNVIIKDGHQ
  • Signal peptide:  MLRSVWVYSLGLAVLLQQSGRE
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Endogenous orexigenic opiate.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q91082-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003859_AF2.pdbhor003859_ESM.pdb

Physical Information

Mass: 456743 Formula: C181H286N50O49S
Absent amino acids: AC Common amino acids: K
pI: 10.58 Basic residues: 8
Polar residues: 9 Hydrophobic residues: 9
Hydrophobicity: -91.76 Boman Index: -6686
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 65.88
Instability Index: 1779.41 Extinction Coefficient cystines: 6990
Absorbance 280nm: 211.82

Literature

  • PubMed ID:  9268621
  • Title:  Deciphering Posttranslational Processing Events in the Pituitary of a Neopterygian Fish: Cloning of a Gar Proopiomelanocortin cDNA