HORDB

ID: hor003822
Uniprot ID: P87352
Protein name: Melanocyte-stimulating hormone beta
Gene name: pomc
Organism: Acipenser transmontanus (White sturgeon)
Family: POMC family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Acipenser (genus), Acipenserini (tribe), Acipenserinae (subfamily), Acipenseridae (family), Acipenseroidei (suborder), Acipenseriformes (order), Chondrostei (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: DGSYKMNHFRWSGPPKD
Length: 17(211-227)
Propeptide: MLHPVWGCVVAVMGVLWFYSSGVQSQCWEHSQCRDLASEANILECIQACKVDLSAESPLFPGNGHLQPTSEDIQNYVMSHFHWNTFGQRMNGTPGGSKREGASTALSVLLEALSQPRDEVERESEEEEGLQQHRRDDKRSYSMEHFRWGKPVGRKRRPVKVYPNGVEEESAESYPAEIRRDLSLKLDYPQGEELEEVFGGENDLLNLQKKDGSYKMNHFRWSGPPKDKRYGGFMKSWDERSQKPLLTLFKNVMIK
Signal peptide: MLHPVWGCVVAVMGVLWFYSSGVQS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Increases the pigmentation of skin by increasing melanin production in melanocytes.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003822_AF2.pdb

hor003822_ESM.pdb

Mass:	230778	Formula:	C90H128N26O26S
Absent amino acids:	ACEILQTV	Common amino acids:	DGKPS
pI:	9.26	Basic residues:	4
Polar residues:	6	Hydrophobic residues:	2
Hydrophobicity:	-171.18	Boman Index:	-5216
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	0
Instability Index:	6751.18	Extinction Coefficient cystines:	6990
Absorbance 280nm:	436.88