HORDB

ID: hor003820
Uniprot ID: P87352
Protein name: Gamma-melanotropin-like segment
Gene name: pomc
Organism: Acipenser transmontanus (White sturgeon)
Family: POMC family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Acipenser (genus), Acipenserini (tribe), Acipenserinae (subfamily), Acipenseridae (family), Acipenseroidei (suborder), Acipenseriformes (order), Chondrostei (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: NYVMSHFHWNTFGQRMNGTPGGS
Length: 23
Propeptide: MLHPVWGCVVAVMGVLWFYSSGVQSQCWEHSQCRDLASEANILECIQACKVDLSAESPLFPGNGHLQPTSEDIQNYVMSHFHWNTFGQRMNGTPGGSKREGASTALSVLLEALSQPRDEVERESEEEEGLQQHRRDDKRSYSMEHFRWGKPVGRKRRPVKVYPNGVEEESAESYPAEIRRDLSLKLDYPQGEELEEVFGGENDLLNLQKKDGSYKMNHFRWSGPPKDKRYGGFMKSWDERSQKPLLTLFKNVMIKDGHEKKGQ
Signal peptide: MLHPVWGCVVAVMGVLWFYSSGVQS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: [Corticotropin]: Stimulates the adrenal glands to release cortisol.; [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes.; [Beta-endorphin]: Endogenous orexigenic opiate.; [Met-enkephalin]: Endogenous opiate.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003820_AF2.pdb

hor003820_ESM.pdb

Mass:	301845	Formula:	C115H161N35O33S2
Absent amino acids:	ACDEIKL	Common amino acids:	G
pI:	9.35	Basic residues:	3
Polar residues:	12	Hydrophobic residues:	4
Hydrophobicity:	-85.65	Boman Index:	-4099
Half-Life:	1.4 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	12.61
Instability Index:	2508.7	Extinction Coefficient cystines:	6990
Absorbance 280nm:	317.73