General Information

  • ID:  hor003733
  • Uniprot ID:  P41837
  • Protein name:  Periviscerokinin-1
  • Gene name:  NA
  • Organism:  Periplaneta americana (American cockroach) (Blatta americana)
  • Family:  Periviscerokinin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Periplaneta (genus), Blattinae (subfamily), Blattidae (family), Blattoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GASGLIPVMRN
  • Length:  11(1-11)
  • Propeptide:  GASGLIPVMRN
  • Signal peptide:  NA
  • Modification:  T11 Asparagine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myotropic activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003733_AF2.pdbhor003733_ESM.pdb

Physical Information

Mass: 129288 Formula: C47H83N15O14S
Absent amino acids: CDEFHKQTWY Common amino acids: G
pI: 10.55 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 4
Hydrophobicity: 45.45 Boman Index: -504
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 106.36
Instability Index: 2062.73 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  7716075
  • Title:  Periviscerokinin (Pea-PVK): A Novel Myotropic Neuropeptide From the Perisympathetic Organs of the American Cockroach.
  • PubMed ID:  19257902
  • Title:  A proteomic approach for studying insect phylogeny: CAPA peptides of ancient insect taxa (Dictyoptera, Blattoptera) as a test case.