HORDB

ID: hor003332
Uniprot ID: P01212
Protein name: Synenkephalin
Gene name: penk-a
Organism: Xenopus laevis (African clawed frog)
Family: Opioid neuropeptide precursor family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0001515 opioid peptide activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: DCSKDCASCALHLGQQREINSLACTLECEGKLPSAKAWGTCKELLLLTKVDNVQDGEKYQDNNDSHYAA
Length: 69(25-93)
Propeptide: MGLEARHCCMFLLVFASLSVEIRADCSKDCASCALHLGQQREINSLACTLECEGKLPSAKAWGTCKELLLLTKVDNVQDGEKYQDNNDSHYAAKKYGGFMKRYGGFMKKMDELYHAEPEEDDAGGEILAKNYGGFMKKEYDSDRDAADLLRELLATSGDPESSIYHDNNSETPGEINKRYGGFMRGYRRSTDLEDETSGIQKRYGGFMRRVGRPEWWEDYQKRYGGFMTRFTDSFLPSDEDGESYSKENPDMEKR
Signal peptide: MGLEARHCCMFLLVFASLSVEIRA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Enkephalin neuropeptides compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003332_AF2.pdb

hor003332_ESM.pdb

Mass:	875858	Formula:	C317H507N91O110S6
Absent amino acids:	FM	Common amino acids:	L
pI:	4.66	Basic residues:	9
Polar residues:	24	Hydrophobic residues:	20
Hydrophobicity:	-56.38	Boman Index:	-13390
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	75.07
Instability Index:	5155.36	Extinction Coefficient cystines:	8855
Absorbance 280nm:	130.22