General Information

  • ID:  hor003328
  • Uniprot ID:  P55791
  • Protein name:  Nociceptin
  • Gene name:  PNOC
  • Organism:  Sus scrofa (Pig)
  • Family:  Opioid neuropeptide precursor family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0001515 opioid peptide activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission
  • GO CC:  GO:0005576 extracellular region; GO:0045202 synapse

Sequence Information

  • Sequence:  FGGFTGARKSARKLANQ
  • Length:  17(1-17)
  • Propeptide:  FGGFTGARKSARKLANQ
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. When administered intracerebroventricularly into mice, this peptide induces hyperalgesia and decreases
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: 64卤1 minutes; /3840 seconds ( PubMed ID: 17532097 )

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P55791-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P55791-F1.pdbhor003328_AF2.pdbhor003328_ESM.pdb

Physical Information

Mass: 209463 Formula: C79H129N27O22
Absent amino acids: CDEHIMPVWY Common amino acids: AG
pI: 12.53 Basic residues: 4
Polar residues: 6 Hydrophobic residues: 6
Hydrophobicity: -68.82 Boman Index: -3996
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 40.59
Instability Index: -274.71 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  7481766##17532097
  • Title:  Orphanin FQ: a neuropeptide that activates an opioid neuropeptide precursor familylike G protein-coupled receptor.