HORDB

ID: hor003327
Uniprot ID: P01214
Protein name: Rimorphin
Gene name: PDYN
Organism: Sus scrofa (Pig)
Family: Opioid neuropeptide precursor family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0001515 opioid peptide activity; GO:0031628 opioid receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0007600 sensory perception
GO CC: GO:0005576 extracellular region; GO:0005886 plasma membrane; GO:0030425 dendrite; GO:0043025 neuronal cell body; GO:0043679 axon terminus

Sequence: YGGFLRRQFKVVT
Length: 13(228-240)
Propeptide: MAWQGLLLAACLLVLPSTMADCLSGCSLCAVKTQDGPKPINPLICSLECQAALQPAEEWERCQGLLSFLAPLSLGLEGKEDLESKAALEEPSSELVKYMGPFLKELEKNRFLLSTPAEETSLSRSLVEKLRSLPGRLGEETESELMGDAQQNDGAMEAAALDSSVEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDRDKVGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYYEELFD
Signal peptide: MAWQGLLLAACLLVLPSTMA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).
Mechanism: NA
Cross BBB: NA
Target: OPRK1
Target Unid: F1RSG5
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003327_AF2.pdb

hor003327_ESM.pdb

Mass:	178507	Formula:	C74H115N21O17
Absent amino acids:	ACDEHIMNPSW	Common amino acids:	FGRV
pI:	11.53	Basic residues:	3
Polar residues:	4	Hydrophobic residues:	5
Hydrophobicity:	-10.77	Boman Index:	-2280
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	74.62
Instability Index:	5546.15	Extinction Coefficient cystines:	1490
Absorbance 280nm:	124.17