General Information

  • ID:  hor003278
  • Uniprot ID:  P01213
  • Protein name:  Dynorphin A(1-13)
  • Gene name:  PDYN
  • Organism:  Homo sapiens (Human)
  • Family:  Opioid neuropeptide precursor family
  • Source:  Human
  • Expression:  NA
  • Disease:  Diseases associated with PDYN include Spinocerebellar Ataxia 23 and Cocaine Dependence.
  • Comments:  NA
  • Taxonomy:  Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0001515 opioid peptide activity; GO:0031628 opioid receptor binding
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0007600 sensory perception
  • GO CC:  GO:0005576 extracellular region; GO:0005886 plasma membrane; GO:0030425 dendrite; GO:0043025 neuronal cell body; GO:0043679 axon terminus; GO:0098686 hippocampal mossy fiber to CA3 synapse; GO:0098992 neuronal dense core vesicle

Sequence Information

  • Sequence:  YGGFLRRIRPKLK
  • Length:  13(207-219)
  • Propeptide:  MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA
  • Signal peptide:  MAWQGLVLAACLLMFPSTTA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).
  • Mechanism:  NA
  • Cross BBB:  YES
  • Target:  OPRK1
  • Target Unid:   P41145
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  2n2f(PDB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    2n2f.pdbhor003278_AF2.pdbhor003278_ESM.pdb

Physical Information

Mass: 181819 Formula: C75H126N24O15
Absent amino acids: ACDEHMNQSTVW Common amino acids: R
pI: 12.25 Basic residues: 5
Polar residues: 3 Hydrophobic residues: 4
Hydrophobicity: -77.69 Boman Index: -3638
Half-Life / Aliphatic Index: 2.8 hour Aliphatic Index: 90
Instability Index: 7282.31 Extinction Coefficient cystines: 1490
Absorbance 280nm: 124.17

Literature

  • PubMed ID:  17316701
  • Title:  Dynorphin Peptides Differentially Regulate the Human Kappa opioid neuropeptide precursor family Receptor