HORDB

ID: hor003260
Uniprot ID: Q95104
Protein name: Leumorphin
Gene name: PDYN
Organism: Bos taurus (Bovine)
Family: Opioid neuropeptide precursor family
Source: Animal
Expression: pituitary gland,striatum and hypothalamus
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0001515 opioid peptide activity; GO:0031628 opioid receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0007600 sensory perception
GO CC: GO:0005576 extracellular region; GO:0005886 plasma membrane; GO:0030425 dendrite; GO:0043025 neuronal cell body; GO:0043679 axon terminus

Sequence: YGGFLRRQFKVVTRSQEDPSAYYEELFDV
Length: 29(230-258)
Propeptide: MVWQGLVLAACLLALPSVTADCLAQCSLCAVKTQDGPQPINPLVCSLECQAALQPAQEWERCQGLLSFLTPFTVGLNGKEDLKSKTVLEESSSEPAKHIRPYLKELEKNRFLLSTPAEKNALSSSLVEKLRGLSGRLGEDAESELMGDAQLNDGALEAEARDSNEEEPKEQVKRYGGFLRKYPKRSSEVTGKEAGEGEGGEVGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPSAYYEEL
Signal peptide: MVWQGLVLAACLLALPSVTA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
Mechanism: NA
Cross BBB: NA
Target: OPRM1
Target Unid: P79350
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003260_AF2.pdb

hor003260_ESM.pdb

Mass:	400046	Formula:	C160H235N41O48
Absent amino acids:	CHIMNW	Common amino acids:	EFRVY
pI:	4.67	Basic residues:	4
Polar residues:	8	Hydrophobic residues:	9
Hydrophobicity:	-69.31	Boman Index:	-7446
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	60.34
Instability Index:	8924.83	Extinction Coefficient cystines:	4470
Absorbance 280nm:	159.64