General Information

  • ID:  hor003213
  • Uniprot ID:  NA
  • Protein name:  Alpha-melanocyte-stimulating hormone
  • Gene name:  NA
  • Organism:  NA
  • Family:  POMC family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  SYSMEHFRWGKPV
  • Length:  13
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T13 Valine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Regulate pigmentation of the skin
  • Mechanism:  NA
  • Cross BBB:  YES
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor003213_AF2.pdbhor003213_ESM.pdb

Physical Information

Mass: 183805 Formula: C75H106N20O19S
Absent amino acids: ACDILNQT Common amino acids: S
pI: 9.3 Basic residues: 3
Polar residues: 4 Hydrophobic residues: 3
Hydrophobicity: -92.31 Boman Index: -2624
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 22.31
Instability Index: 3402.31 Extinction Coefficient cystines: 6990
Absorbance 280nm: 582.5

Literature

  • PubMed ID:  12063121
  • Title:  Activity and Conformation of a Cyclic Heptapeptide Possessing the Message Sequence His-Phe-Arg-Trp of Alpha-Melanotropin