General Information

  • ID:  hor003136
  • Uniprot ID:  P84006
  • Protein name:  Peptide tyrosine phenylalanine 2
  • Gene name:  NA
  • Organism:  Penaeus monodon (Giant tiger prawn)
  • Family:  NPY family
  • Source:  animal
  • Expression:  Limited to neuronal cell bodies, neuronal processes and sinus gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Penaeus (genus), Penaeidae (family), Penaeoidea (superfamily), Dendrobranchiata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YSQVSRPRF
  • Length:  9(1-9)
  • Propeptide:  YSQVSRPRF
  • Signal peptide:  NA
  • Modification:  T9 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May act as a neurotransmitter, neuromodulator or neurohormone.
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003136_AF2.pdbhor003136_ESM.pdb

Physical Information

Mass: 128213 Formula: C51H78N16O14
Absent amino acids: ACDEGHIKLMNTW Common amino acids: RS
pI: 11.15 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 2
Hydrophobicity: -111.11 Boman Index: -3530
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 32.22
Instability Index: 5633.33 Extinction Coefficient cystines: 1490
Absorbance 280nm: 186.25

Literature

  • PubMed ID:  12431727
  • Title:  Four novel PYFs: members of NPY/PP peptide superfamily from the eyestalk of the giant tiger prawn Penaeus monodon.