HORDB

ID: hor003122
Uniprot ID: A0SIF1
Protein name: sNPF peptide 3
Gene name: sNPF
Organism: Anopheles gambiae (African malaria mosquito)
Family: NPY family
Source: Animal
Expression: Expressed in all body parts of larva, pupae and adults.
Disease: NA
Comments: NA
Taxonomy: gambiae species complex, Pyretophorus, Cellia (subgenus), Anopheles (genus), Anophelinae (subfamily), Culicidae (family), Culicoidea (superfamily), Culicomorpha (infraorder), Nematocera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0032095 regulation of response to food; GO:0040014 regulation of multicellular organism growth
GO CC: GO:0005576 extracellular region

Sequence: SNLFGNLVNQFQQDDVMQQ
Length: 19(135-153)
Propeptide: MYRINLTTFTLLLVLAVGSLMSESLHPSDGAINDLYEYLLQREYAAPVSYADHQIKRKAVRSPSLRLRFGRRSDPSVPLRPEEDELIDQKAIRAPQLRLRFGRNDPLWTSFNENALLEENFEKRAPSQRLRWGRSNLFGNLVNQFQQDDVMQQKTIRAPQLRLRFGRTDPSWAMYNEHQLTTGQQAQPANEASEKRAPTQRLRWGRSDPALAKDSSEDKALDVEESENTNADDK
Signal peptide: MYRINLTTFTLLLVLAVGSLMS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Has a role in inhibiting host-seeking behavior during a reproductive cycle
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q9LNN7-F1.pdb

hor003122_AF2.pdb

hor003122_ESM.pdb

Mass:	254668	Formula:	C95H145N27O33S
Absent amino acids:	ACEHIKPRTWY	Common amino acids:	Q
pI:	3.49	Basic residues:	0
Polar residues:	5	Hydrophobic residues:	6
Hydrophobicity:	-66.84	Boman Index:	-4129
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	71.58
Instability Index:	2351.05	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 17140700
Title: Characterization and Expression of the Short Neuropeptide F Receptor in the African Malaria Mosquito, Anopheles Gambiae