General Information

  • ID:  hor003084
  • Uniprot ID:  A0SIX6
  • Protein name:  sNPF-2
  • Gene name:  sNPF
  • Organism:  Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
  • Family:  NPY family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Stegomyia (subgenus), Aedes (genus), Aedini (tribe), Culicinae (subfamily), Culicidae (family), Culicoidea (superfamily), Culicomorpha (infraorder), Nematocera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0032095 regulation of response to food; GO:0040014 regulation of multicellular organism growth
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  APQLRLRF
  • Length:  8
  • Propeptide:  MCRINFTTLSLILVLWSGSLMSEPSQNADGSIKGLYEYLLQREYAAPVSYADHQIKRKAVRSPSLRLRFGRRSDPSVPVEPEDDDMVDQRSIRAPQLRLRFGRTDPLWSSFNENALLEEKRAPSQRLRWGRSGGGMFSTNDVMQQKAIRAPQLRLRFGRSDPSWAMFNEHQLDEQQFADATRQPSKTLRGDEPTSIESTEQVESEENSPSNMDEK
  • Signal peptide:  MCRINFTTLSLILVLWSGSLMS
  • Modification:  T8 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Plays a role in controlling food intake and regulating body size.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0SIX6-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor003084_AF2.pdbhor003084_ESM.pdb

Physical Information

Mass: 112525 Formula: C46H77N15O10
Absent amino acids: CDEGHIKMNSTVWY Common amino acids: LR
pI: 12.5 Basic residues: 2
Polar residues: 0 Hydrophobic residues: 4
Hydrophobicity: -23.75 Boman Index: -2075
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 110
Instability Index: 10505 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  20163154
  • Title:  Neuropeptidomics of the Mosquito Aedes Aegypti