General Information

  • ID:  hor003080
  • Uniprot ID:  Q9PS46
  • Protein name:  Pancreatic polypeptide
  • Gene name:  NA
  • Organism:  Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
  • Family:  NPY family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Scyliorhinus (genus), Scyliorhinidae (family), Carcharhiniformes (order), Galeoidea (superorder), Galeomorphii, Selachii (infraclass), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YPSKPDNPGEGAPAEDLAKYYSALRHYINLITRQRY
  • Length:  36
  • Propeptide:  YPSKPDNPGEGAPAEDLAKYYSALRHYINLITRQRY
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9PS46-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    AF-Q9PS46-F1.pdbhor003080_AF2.pdbhor003080_ESM.pdb

Physical Information

Mass: 479310 Formula: C188H284N52O56
Absent amino acids: CFMVW Common amino acids: Y
pI: 8.91 Basic residues: 6
Polar residues: 12 Hydrophobic residues: 9
Hydrophobicity: -103.89 Boman Index: -8675
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 65.28
Instability Index: 5469.72 Extinction Coefficient cystines: 7450
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  1523163
  • Title:  Structural Characterization of Neuropeptide Y From the Brain of the Dogfish, Scyliorhinus Canicula