HORDB

ID: hor003071
Uniprot ID: P01156
Protein name: Neuromedin N
Gene name: NTS
Organism: Bos taurus (Bovine)
Family: Neurotensin family
Source: animal
Expression: Brain and gut.
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity; GO:0048018 receptor ligand activity; GO:0071855 neuropeptide receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region; GO:0030133 transport vesicle; GO:0031410 cytoplasmic vesicle; GO:0043231 intracellular membrane-bounded organelle; GO:0043679 axon terminus

Sequence: KIPYIL
Length: 6
Propeptide: MMAGMKIQLVCMILLAFSSWSLCSDSEEEMKALETDLLTNMHTSKISKASVPSWKMSLLNVCSLINNLNSQAEETGEFHEEELITRRKFPAALDGFSLEAMLTIYQLQKICHSRAFQHWELIQEDILDAGNDKNEKEEVIKRKIPYILKRQLYENKPRRPYILKRGSYYY
Signal peptide: MMAGMKIQLVCMILLAFSSWSLC
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: May play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle
Mechanism: NA
Cross BBB: YES
Target: NTSR1
Target Unid: F1MWG2
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-A8MQM7-F1.pdb

hor003071_AF2.pdb

hor003071_ESM.pdb

Mass:	83533	Formula:	C38H63N7O8
Absent amino acids:	ACDEFGHMNQRSTVW	Common amino acids:	I
pI:	9.3	Basic residues:	1
Polar residues:	1	Hydrophobic residues:	3
Hydrophobicity:	100	Boman Index:	907
Half-Life:	1.3 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	195
Instability Index:	2148.33	Extinction Coefficient cystines:	1490
Absorbance 280nm:	298