General Information

  • ID:  hor003061
  • Uniprot ID:  NA
  • Protein name:  Neurotensin
  • Gene name:  NA
  • Organism:  Rattus norvegicus
  • Family:  Neurotensin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  RKPWLL
  • Length:  6
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  YES
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor003061_AF2.pdbhor003061_ESM.pdb

Physical Information

Mass: 90139 Formula: C40H65N11O7
Absent amino acids: ACDEFGHIMNQSTVY Common amino acids: L
pI: 11.65 Basic residues: 2
Polar residues: 0 Hydrophobic residues: 3
Hydrophobicity: -55 Boman Index: -830
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 130
Instability Index: 1153.33 Extinction Coefficient cystines: 5500
Absorbance 280nm: 1100

Literature

  • PubMed ID:  8369751
  • Title:  Pharmacokinetics of Novel Hexapeptides With Neurotensin Activity in Rats