General Information

  • ID:  hor003022
  • Uniprot ID:  NA
  • Protein name:  Neuromedin U-8
  • Gene name:  NA
  • Organism:  Canis familiaris
  • Family:  NmU family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  EFLFRPRN
  • Length:  8
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T8 Asparagine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  smooth muscle contractile activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003022_AF2.pdbhor003022_ESM.pdb

Physical Information

Mass: 120326 Formula: C50H75N15O12
Absent amino acids: ACDGHIKMQSTVWY Common amino acids: FR
pI: 10.4 Basic residues: 2
Polar residues: 1 Hydrophobic residues: 3
Hydrophobicity: -102.5 Boman Index: -3241
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 48.75
Instability Index: 3882.5 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  10959581
  • Title:  Structure-activity Relationships of Neuromedin U. IV. Absolute Requirement of the Arginine Residue at Position 7 of Dog Neuromedin U-8 for Contractile Activity