HORDB

ID: hor002973
Uniprot ID: P18909
Protein name: ANP-24
Gene name: NA
Organism: Lithobates catesbeianus (American bullfrog) (Rana catesbeiana)
Family: Natriuretic peptide family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Lithobates (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0006182 cGMP biosynthetic process; GO:0007168 receptor guanylyl cyclase signaling pathway; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region

Sequence: SSDCFGSRIDRIGAQSGMGCGRRF
Length: 24
Propeptide: MGTSFVGYLTFVLLLLALTKVRGGPAYNSPLSSDLSDLKGLLERLEDRLPVEEVETPVQDIFAPNYDSADSSNSAPSLTVEAARPGADMMYNRGSWTQQEKSSPLRNKLRELLNAPRSMRRSSDCFGSRIDRIGAQSGMGCGRRF
Signal peptide: MGTSFVGYLTFVLLLLALTKVRG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q4PSX1-F1.pdb

hor002973_AF2.pdb

hor002973_ESM.pdb

Mass:	297429	Formula:	C103H167N37O34S3
Absent amino acids:	EHKLNPTVWY	Common amino acids:	G
pI:	8.83	Basic residues:	4
Polar residues:	11	Hydrophobic residues:	5
Hydrophobicity:	-43.33	Boman Index:	-6904
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	36.67
Instability Index:	6112.92	Extinction Coefficient cystines:	125
Absorbance 280nm:	5.43