General Information

  • ID:  hor002934
  • Uniprot ID:  P85069
  • Protein name:  Ovarian jelly-peptide 2
  • Gene name:  NA
  • Organism:  Sepia officinalis (Common cuttlefish)
  • Family:  NA
  • Source:  Animal
  • Expression:  Vitellogenic follicle, fully grown oocyte, egg and internal egg-capsule (at protein level). Not detected in previtellogenic follicles, external egg-capsule, central nervous system and hemolymph.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Sepia (genus), Sepiidae (family), Sepiina (suborder), Sepiida (order), Decapodiformes (superorder), Coleoidea (subclass), Cephalopoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0006937 regulation of muscle contraction; GO:0007218 neuropeptide signaling pathway; GO:0019953 sexual reproduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DEVKIVL
  • Length:  7(1-7)
  • Propeptide:  DEVKIVLD
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Has myotropic activity targeting the genital tract.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002934_AF2.pdbhor002934_ESM.pdb

Physical Information

Mass: 92219 Formula: C37H66N8O12
Absent amino acids: ACFGHMNPQRSTWY Common amino acids: V
pI: 4.18 Basic residues: 1
Polar residues: 0 Hydrophobic residues: 4
Hydrophobicity: 82.86 Boman Index: -316
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 194.29
Instability Index: -1980 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  16434122
  • Title:  Ovarian jelly-peptides (OJPs), a new family of regulatory peptides identified in the cephalopod Sepia officinalis.