General Information

  • ID:  hor002869
  • Uniprot ID:  Q9NDE8
  • Protein name:  GPPRFI-amide
  • Gene name:  MRP
  • Organism:  Aplysia californica (California sea hare)
  • Family:  NA
  • Source:  Animal
  • Expression:  Expressed in the CNS and peripheral tissues (the digestive tract, vasculature, and the reproductive organs).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GPPRFI
  • Length:  6(623-628)
  • Propeptide:  MCTRPGLAALLVLMTSCASSFSRADTQSASAAALSAASADAQAARQQQEQHLVAQQQQQQQQQQQHSNNNEPQQRAPSLDPYYRSLLDGSQGGQLFAPAQPVSQPDLSPDFSNPMGSSLSQSGTPEDSDTKVDTRGAAPKFFGKKRGQAPRFFGKKRAMAPKFFGKKSSEFPTSNSEQLALDTRGSPRFFGKKSFPESNREQRGSPRFFGKKRFDENVDIDERAAPRFFGKKSSGESAGDSGYISVASRGSPRFF
  • Signal peptide:  MCTRPGLAALLVLMTSCASS
  • Modification:  T6 Isoleucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Be inhibitory on Aplysia esophagus, penis retractor muscle, and body wall muscle
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9NDE8-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002869_AF2.pdbhor002869_ESM.pdb

Physical Information

Mass: 77518 Formula: C33H51N9O7
Absent amino acids: ACDEHKLMNQSTVWY Common amino acids: P
pI: 10.55 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 2
Hydrophobicity: -13.33 Boman Index: -608
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 65
Instability Index: 2786.67 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  10531464
  • Title:  The Aplysia mytilus inhibitory peptide-related peptides: identification, cloning, processing, distribution, and action.